Physical Activity and Gallstone Disease

А im: to present data of Russian and foreign studies about association between physical activity (PA) gallstone disease (GSD). Key point. A low PA level is one the four major risk factors for chronic non-infectiuos diseases. The frequency in men women Federation (according medical examination 2016) 19 %. global prevalence GSD up 20 % among adults. Many systematic reviews meta-analyses have confirmed an inverse world, regardless potential GSD, with a clear dose-dependent effect — relative (RR) was 0.87 (95 CI 0.83–0.92) per metabolic equivalents (MET) week. According our results epidemiological survey framework WHO MONICA program Novosibirsk ( n = 870) aged 25–64 total (less than 800 MET/min/week), as well first class leisure-time, occurred much more often (class 1 33 %, classes 2–4 8.7–11.0 p < 0.01). favorably affects almost all mechanisms formation: improves cholesterol metabolism bile, increases serum HDL cholesterol, bile acid synthesis, stimulates release cholecystokinin, reduces mucin hypersecretion, diversity richness intestinal microbiota. Daily serves preventive measure GSD: reduced by 66 0.18–0.86). Conclusion. EASL has recognized protective agent against formation.